Theorie:

Idioms about town. Part 2
  
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Hit town - to arrive in town;

Out of town - temporarily not in one's own town;

Out on the town - celebrating at one or more places in a town;

Paint the town - to go out and celebrate; to go on a drinking about; to get drunk;

Paint the town red - to go out and enjoy yourself in the evening, often drinking a lot of alcohol and dancing;

Talk of the town - a subject of considerable gossip;

The only game in town - the only choice, which one must accept for want of a better one;

Town and gown - the inhabitants of a college or university town and the students and personnel of the college.
 
Examples:

The minute he hit town, he checked into a hotel and took a long nap.

I'll go out of town next week. I'm going to be at a conference. I take care of Mary's cat when she's out of town.

I'm really tired. I was out on the town until dawn. We went out on the town to celebrate our wedding anniversary.

Jack finished his exams today so he's gone out to paint the town red.